Search results for " INSPIRE"
showing 10 items of 25 documents
Mechanical ventilation parameters in critically ill COVID-19 patients: a scoping review
2021
Abstract Background The mortality of critically ill patients with COVID-19 is high, particularly among those receiving mechanical ventilation (MV). Despite the high number of patients treated worldwide, data on respiratory mechanics are currently scarce and the optimal setting of MV remains to be defined. This scoping review aims to provide an overview of available data about respiratory mechanics, gas exchange and MV settings in patients admitted to intensive care units (ICUs) for COVID-19-associated acute respiratory failure, and to identify knowledge gaps. Main text PubMed, EMBASE, and MEDLINE databases were searched from inception to October 30, 2020 for studies providing at least one v…
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: Insights from the LUNG SAFE study
2020
Abstract Background Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence o…
A Survey on Nature-Inspired Medical Image Analysis: A Step Further in Biomedical Data Integration
2019
Natural phenomena and mechanisms have always intrigued humans, inspiring the design of effective solutions for real-world problems. Indeed, fascinating processes occur in nature, giving rise to an ever-increasing scientific interest. In everyday life, the amount of heterogeneous biomedical data is increasing more and more thanks to the advances in image acquisition modalities and high-throughput technologies. The automated analysis of these large-scale datasets creates new compelling challenges for data-driven and model-based computational methods. The application of intelligent algorithms, which mimic natural phenomena, is emerging as an effective paradigm for tackling complex problems, by…
A spiking network for body size learning inspired by the fruit fly
2013
The concept of peripersonal space is an interesting research topics for psychologists, neurobiologists and for robotic applications. A living being can learn the representation of its own body to take the correct behavioral decision when interacting with the world. To transfer these important learning mechanisms on bio-robots, simple and efficient solutions can be found in the insect world. In this paper a neural-based model for body-size learning is proposed taking into account the results obtained in experiments with fruit flies. Simulations and experimental results on a roving platform are reported and compared with the biological counterpart.
CADASTRAL MODELS IN EU MEMBER STATES
2019
Abstract Cadastres are always related to land: they are a creation of man as effect of his relationship with land. The different conditions of the Cadastre in 14 EU Member States, including the former EU Candidate States (that nowadays are also EU members), are shown in this paper. Half of EU countries store cadastral and registration data in the same database. Basically two original models of cadastral system exist in the EU, related with systems of land registration : 1) in the Central European model (beyond the area of the Germanic “Grundbuch”) Cadastre emerges as a graphic basis (map) of land registration (Land Registry), so that physical changes must be reflected in the Cadastre and le…
How to engineer biologically inspired cognitive architectures
2013
Biologically inspired cognitive architectures are complex systems where different modules of cognition interact in order to reach the global goals of the system in a changing environment. Engineering and modeling this kind of systems is a hard task due to the lack of techniques for developing and implementing features like learning, knowledge, experience, memory, adaptivity in an inter-modular fashion. We propose a new concept of intelligent agent as abstraction for developing biologically cognitive architectures. © 2013 Springer-Verlag.
PESI - a taxonomic backbone for Europe
2015
Reliable taxonomy underpins communication in all of biology, not least nature conservation and sustainable use of ecosystem resources. The flexibility of taxonomic interpretations, however, presents a serious challenge for end-users of taxonomic concepts. Users need standardised and continuously harmonised taxonomic reference systems, as well as highquality and complete taxonomic data sets, but these are generally lacking for nonspecialists. The solution is in dynamic, expertly curated web-based taxonomic tools. The Pan-European Species-directories Infrastructure (PESI) worked to solve this key issue by providing a taxonomic e-infrastructure for Europe. It strengthened the relevant social (…
Supplemental Perioperative Oxygen and the Risk of Surgical Wound Infection: A Randomized Controlled Trial
2006
ABSTRACT Three hundred patients were enrolled in a double-blind, randomized, controlled study designed to investigate the ability of supplemental perioperative oxygen to reduce wound infection. Participants were age 18 to 80 years, had no coexisting serious medical conditions, and were scheduled to undergo elective colorectal surgery at one of 14 participating hospitals in Spain. No patients undergoing minor or laparoscopic surgery were included. Anesthesia and antibiotic prophylaxis were standardized for the study. Patients were randomized by computer-generated codes to receive an oxygen/air mixture of 30% or 80% fraction of inspired oxygen (F102) intraoperatively and postoperatively for 6…
LACTATE, NOT GLUCOSE, UP-REGULATES MITOCHONDRIAL OXYGEN CONSUMPTION BOTHIN SHAM AND LATERAL FLUID PERCUSSED RAT BRAINS
2006
OBJECTIVE: Failure of energy metabolism after traumatic brain injury may be a major factor limiting outcome. Although glucose is the primary metabolic substrate in the healthy brain, the well documented surge in tissue lactate after traumatic brain injury suggests that lactate may provide an energy need that cannot be met by glucose. We hypothesized, therefore, that administration of lactate or the combination of lactate and supraphysiological oxygen may improve mitochondrial oxidative respiration in the brain after rat fluid percussion injury. We measured oxygen consumption (VO2) to determine what effects glucose, lactate, oxygen, and the combination of lactate and oxygen have on mitochond…
Closed-Loop Automatic Oxygen Control (CLAC) in Preterm Infants: A Randomized Controlled Trial
2014
BACKGROUND AND OBJECTIVE: In preterm infants receiving supplemental oxygen, routine manual control (RMC) of the fraction of inspired oxygen (FIO2) is often difficult and time consuming. We developed a system for closed-loop automatic control (CLAC) of the FIO2 and demonstrated its short-term safety and efficacy in a single-center study. The objective of this study was to test the hypothesis that this system is more effective than RMC alone in maintaining arterial oxygen saturation within target levels when evaluated over 24 hours under routine conditions and with different target levels. METHODS: We performed a multicenter, randomized controlled, crossover clinical trial in 34 preterm infa…